Gentamicin ototoxicity can be defined as gentamicin which has the potential to cause toxic reactions in structures in the inner ear such as the cochlea. And vestibule. Damage on structures This Which due to by using the drug can cause symptoms such as hearing loss, tinnitus and disturbance balance. Ototoxicity defined as damage in the cochlear and/or vestibular structures in the ear due to exposure to chemicals 1.
Damage to the inner ear caused by the use of certain drugs is often found in everyday medical practice. In developing countries, where drugs such as aminoglycosides are often used on disease like pneumonia, diarrhea And tuberculosis lungs, so that the incidence of ototoxicity is quite high. As a clinician, a doctor must know that ototoxic drugs can cause damage to the hearing and balance systems so that a doctor must recognize the types of drugs that are ototoxic 1 .
Moment This agent pharmacological with effect side ototoxicity has are widely known and include aminoglycosides, platinum-based antineoplastic agents, salicylates, quinine, and diuretics 1 .
Drugs that have the potential to cause toxic reactions to the structures of the inner ear, including the cochlea and vestibular are said to be ototoxic. to structure This is due to the influence of drugs that cause hearing loss, tinnitus, and balance disorders. Cases of ototoxicity became a major concern with the discovery of streptomycin in 1944 by Waxman . Streptomycin was useful in the therapy of tuberculosis, but some patients were later found to have dysfunction cochlear and vestibular irreversible. A few years later, analog from streptomycin that is dihydrostreptomycin used with hope its ototoxic effect is lower than streptomycin. However, in reality, dihydrostreptomycin Also own number incident toxicity to cochlea the high so that withdrawn from circulation 2 .
Considering that cases of ototoxicity can be an emergency, the author considers important For learn more details regarding early diagnosis of ototoxicity induced by aminoglycosides so that rapid and appropriate management can be carried out to prevent more severe damage to the hearing and balance organs.